Uridine Triacetate
نویسندگان
چکیده
منابع مشابه
Emergency use of uridine triacetate for the prevention and treatment of life‐threatening 5‐fluorouracil and capecitabine toxicity
BACKGROUND Increased susceptibility to 5-fluorouracil (5-FU)/capecitabine can lead to rapidly occurring toxicity caused by impaired clearance, dihydropyrimidine dehydrogenase deficiency, and other genetic variations in the enzymes that metabolize 5-FU. Life-threatening 5-FU overdoses occur because of infusion pump errors, dosage miscalculations, and accidental or suicidal ingestion of capecitab...
متن کاملBenzene-1,3,5-triyl triacetate
The asymmetric unit of the title compound, C(12)H(12)O(6), contains two essentially identical mol-ecules related by a pseudo-inversion centre. The three acet-oxy groups in each mol-ecule are essentially planar and are tilted, in a regular propeller-style arrangement, with their normals oriented between 56.72 (12) and 76.35 (9)° from the normal to the mean plane of the central C(6) ring; in each...
متن کاملFDA Approval: Uridine Triacetate for the Treatment of Patients Following Fluorouracil or Capecitabine Overdose or Exhibiting Early-Onset Severe Toxicities Following Administration of These Drugs.
On December 11, 2015, the FDA approved uridine triacetate (VISTOGARD; Wellstat Therapeutics Corporation) for the emergency treatment of adult and pediatric patients following a fluorouracil or capecitabine overdose regardless of the presence of symptoms, and of those who exhibit early-onset, severe, or life-threatening toxicity affecting the cardiac or central nervous system, and/or early onset...
متن کاملTrimethyl 2,2′,2′′-[1,3,5-triazine-2,4,6-triyltris(azanediyl)]triacetate
The title compound, C(12)H(18)N(6)O(6), was synthesized via nucleophilic substitution by reacting 2,4,6-trichloro-1,3,5-triazine with glycine methyl ester hydro-chloride in reflux (dried toluene) under anhydrous atmosphere. Individual mol-ecules self-assemble via strong N-H⋯O hydrogen bonds into supra-molecular double tapes running parallel to the [010] crystallographic direction. The close pac...
متن کاملThe enzymic interconversion of uridine diphosphogalactose and uridine diphosphoglucose.
The reversible transformation of galactose into glucose in biological systems is important both for the utilization of dietary galactose as fuel (via hexose 6-phosphate) and for the biosynthesis of complex galactose-containing compounds from glucose or acetate. The first step in the metabolism of galactose in both yeast and animal tissues is phosphorylation in the 1 position of the hexose to fo...
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ژورنال
عنوان ژورنال: Hospital Pharmacy
سال: 2016
ISSN: 0018-5787,1945-1253
DOI: 10.1310/hpj5106-484